Modeling of Human Genetic Diseases Via Cellular, Reprogramming
نویسندگان
چکیده
منابع مشابه
Modeling of Human Genetic Diseases Via Cellular Re- programming
different in the clinical studies between mouse and human. In fact, many drugs that have been proved to be effective in mouse models do not work well in the patients. Thus, development of new systems for realizing disease-specific phenotypes is needed to explore fundamental mechanisms of various human diseases. In this context, human embryonic stem cells (hESCs) first established by Thomson et ...
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The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
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The remarkable advances in cellular reprogramming have made it possible to generate a renewable source of human neurons from fibroblasts obtained from skin samples of neonates and adults. As a result, we can now investigate the etiology of neurological diseases at the cellular level using neuronal populations derived from patients, which harbor the same genetic mutations thought to be relevant ...
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the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...
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Breakthroughs in cell fate conversion have made it possible to generate large quantities of patient-specific cells for regenerative medicine. Due to multiple advantages of peripheral blood cells over fibroblasts from skin biopsy, the use of blood mononuclear cells (MNCs) instead of skin fibroblasts will expedite reprogramming research and broaden the application of reprogramming technology. Thi...
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ژورنال
عنوان ژورنال: Journal of Genetic Medicine
سال: 2012
ISSN: 1226-1769,2383-8442
DOI: 10.5734/jgm.2012.9.2.67